Combining Precursor and Fragment Information for Improved Detection of Differential Abundance in Data Independent Acquisition

In bottom-up, label-free discovery proteomics, biological samples are acquired in a data-dependent (DDA) or data-independent (DIA) manner, with peptide signals recorded in an intact (MS1) and fragmented (MS2) form. While DDA has only the MS1 space for quantification, DIA contains both MS1 and MS2 at...

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Detalles Bibliográficos
Autores principales: Huang, Ting, Bruderer, Roland, Muntel, Jan, Xuan, Yue, Vitek, Olga, Reiter, Lukas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Biochemistry and Molecular Biology 2020
Materias:
Technological Innovation and Resources
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000113/
https://www.ncbi.nlm.nih.gov/pubmed/31888964
http://dx.doi.org/10.1074/mcp.RA119.001705

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000113/
https://www.ncbi.nlm.nih.gov/pubmed/31888964
http://dx.doi.org/10.1074/mcp.RA119.001705

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