Analysis of RNA-Seq datasets reveals enrichment of tissue-specific splice variants for nuclear envelope proteins

Laminopathies yield tissue-specific pathologies, yet arise from mutation of ubiquitously-expressed genes. A little investigated hypothesis to explain this is that the mutated proteins or their partners have tissue-specific splice variants. To test this, we analyzed RNA-Seq datasets, finding novel is...

Descripción completa

Detalles Bibliográficos
Autores principales: Capitanchik, Charlotte, Dixon, Charles R., Swanson, Selene K., Florens, Laurence, Kerr, Alastair R. W., Schirmer, Eric C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Special Issue on Laminopathies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000147/
https://www.ncbi.nlm.nih.gov/pubmed/29912636
http://dx.doi.org/10.1080/19491034.2018.1469351

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000147/
https://www.ncbi.nlm.nih.gov/pubmed/29912636
http://dx.doi.org/10.1080/19491034.2018.1469351

Ejemplares similares