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Analysis of RNA-Seq datasets reveals enrichment of tissue-specific splice variants for nuclear envelope proteins

Laminopathies yield tissue-specific pathologies, yet arise from mutation of ubiquitously-expressed genes. A little investigated hypothesis to explain this is that the mutated proteins or their partners have tissue-specific splice variants. To test this, we analyzed RNA-Seq datasets, finding novel is...

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Detalles Bibliográficos
Autores principales:	Capitanchik, Charlotte, Dixon, Charles R., Swanson, Selene K., Florens, Laurence, Kerr, Alastair R. W., Schirmer, Eric C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2018
Materias:	Special Issue on Laminopathies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000147/ https://www.ncbi.nlm.nih.gov/pubmed/29912636 http://dx.doi.org/10.1080/19491034.2018.1469351

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