A conformational switch in response to Chi converts RecBCD from phage destruction to DNA repair

The RecBCD complex plays key roles in phage DNA degradation, CRISPR array acquisition (adaptation) and host DNA repair. The switch between these roles is regulated by a DNA sequence called Chi. We report cryo-EM structures of the Escherichia coli RecBCD complex bound to several different DNA forks c...

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Detalles Bibliográficos
Autores principales: Cheng, Kaiying, Wilkinson, Martin, Chaban, Yuriy, Wigley, Dale B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000243/
https://www.ncbi.nlm.nih.gov/pubmed/31907455
http://dx.doi.org/10.1038/s41594-019-0355-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000243/
https://www.ncbi.nlm.nih.gov/pubmed/31907455
http://dx.doi.org/10.1038/s41594-019-0355-2

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