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A conformational switch in response to Chi converts RecBCD from phage destruction to DNA repair
The RecBCD complex plays key roles in phage DNA degradation, CRISPR array acquisition (adaptation) and host DNA repair. The switch between these roles is regulated by a DNA sequence called Chi. We report cryo-EM structures of the Escherichia coli RecBCD complex bound to several different DNA forks c...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000243/ https://www.ncbi.nlm.nih.gov/pubmed/31907455 http://dx.doi.org/10.1038/s41594-019-0355-2 |