Structural insights and activating mutations in diverse pathologies define mechanisms of deregulation for phospholipase C gamma enzymes

BACKGROUND: PLCγ enzymes are key nodes in cellular signal transduction and their mutated and rare variants have been recently implicated in development of a range of diseases with unmet need including cancer, complex immune disorders, inflammation and neurodegenerative diseases. However, molecular n...

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Detalles Bibliográficos
Autores principales: Liu, Yang, Bunney, Tom D., Khosa, Sakshi, Macé, Kévin, Beckenbauer, Katharina, Askwith, Trevor, Maslen, Sarah, Stubbs, Christopher, de Oliveira, Taiana M., Sader, Kasim, Skehel, Mark, Gavin, Anne-Claude, Phillips, Christopher, Katan, Matilda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Research paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000336/
https://www.ncbi.nlm.nih.gov/pubmed/31918402
http://dx.doi.org/10.1016/j.ebiom.2019.102607

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000336/
https://www.ncbi.nlm.nih.gov/pubmed/31918402
http://dx.doi.org/10.1016/j.ebiom.2019.102607

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