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B7H4 expression in tumor cells impairs CD8 T cell responses and tumor immunity

B7 homolog 4 (B7H4) is considered a negative regulator of immune responses, but the immunoregulatory role of B7H4 in the tumor microenvironment is not clear. Here, we assessed B7H4 expression cell types in human breast cancer tissues and addressed its potential mechanisms in the CD8 T cell immune re...

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Detalles Bibliográficos
Autores principales: Zhou, Linlin, Ruan, Mei, Liu, Ying, Zhu, Yanyang, Fu, Deqiang, Wu, Kunlin, Zhang, Qiuyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000514/
https://www.ncbi.nlm.nih.gov/pubmed/31848656
http://dx.doi.org/10.1007/s00262-019-02451-4