Insulin-Like Growth Factor-1 Down-Regulates the Phosphorylation of FXYD1 and Rescues Behavioral Deficits in a Mouse Model of Rett Syndrome

Rett syndrome (RTT) is a neurodevelopmental disease in children that is mainly caused by mutations in the MeCP2 gene, which codes for a transcriptional regulator. The expression of insulin-like growth factor-1 (IGF-1) is reduced in RTT patients and animal models, and IGF-1 treatment is a promising t...

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Detalles Bibliográficos
Autores principales: Yuan, Zhe-Feng, Mao, Shan-Shan, Shen, Jue, Jiang, Li-Hua, Xu, Lu, Xu, Jia-Lu, Gao, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000522/
https://www.ncbi.nlm.nih.gov/pubmed/32063830
http://dx.doi.org/10.3389/fnins.2020.00020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000522/
https://www.ncbi.nlm.nih.gov/pubmed/32063830
http://dx.doi.org/10.3389/fnins.2020.00020

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