Loss of GFAT-1 feedback regulation activates the hexosamine pathway that modulates protein homeostasis

Glutamine fructose-6-phosphate amidotransferase (GFAT) is the key enzyme in the hexosamine pathway (HP) that produces uridine 5′-diphospho-N-acetyl-d-glucosamine (UDP-GlcNAc), linking energy metabolism with posttranslational protein glycosylation. In Caenorhabditis elegans, we previously identified...

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Detalles Bibliográficos
Autores principales: Ruegenberg, Sabine, Horn, Moritz, Pichlo, Christian, Allmeroth, Kira, Baumann, Ulrich, Denzel, Martin S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000685/
https://www.ncbi.nlm.nih.gov/pubmed/32019926
http://dx.doi.org/10.1038/s41467-020-14524-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000685/
https://www.ncbi.nlm.nih.gov/pubmed/32019926
http://dx.doi.org/10.1038/s41467-020-14524-5

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