RyR1-targeted drug discovery pipeline integrating FRET-based high-throughput screening and human myofiber dynamic Ca(2+) assays

Elevated cytoplasmic [Ca(2+)] is characteristic in severe skeletal and cardiac myopathies, diabetes, and neurodegeneration, and partly results from increased Ca(2+) leak from sarcoplasmic reticulum stores via dysregulated ryanodine receptor (RyR) channels. Consequently, RyR is recognized as a high-v...

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Detalles Bibliográficos
Autores principales: Rebbeck, Robyn T., Singh, Daniel P., Janicek, Kevyn A., Bers, Donald M., Thomas, David D., Launikonis, Bradley S., Cornea, Razvan L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000700/
https://www.ncbi.nlm.nih.gov/pubmed/32019969
http://dx.doi.org/10.1038/s41598-020-58461-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000700/
https://www.ncbi.nlm.nih.gov/pubmed/32019969
http://dx.doi.org/10.1038/s41598-020-58461-1

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