Unleashing the full potential of Hsp90 inhibitors as cancer therapeutics through simultaneous inactivation of Hsp90, Grp94, and TRAP1

The Hsp90 family proteins Hsp90, Grp94, and TRAP1 are present in the cell cytoplasm, endoplasmic reticulum, and mitochondria, respectively; all play important roles in tumorigenesis by regulating protein homeostasis in response to stress. Thus, simultaneous inhibition of all Hsp90 paralogs is a reas...

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Detalles Bibliográficos
Autores principales: Park, Hye-Kyung, Yoon, Nam Gu, Lee, Ji-Eun, Hu, Sung, Yoon, Sora, Kim, So Yeon, Hong, Jun-Hee, Nam, Dougu, Chae, Young Chan, Park, Jong Bae, Kang, Byoung Heon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000702/
https://www.ncbi.nlm.nih.gov/pubmed/31956271
http://dx.doi.org/10.1038/s12276-019-0360-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000702/
https://www.ncbi.nlm.nih.gov/pubmed/31956271
http://dx.doi.org/10.1038/s12276-019-0360-x

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