Clinical relevance of TP53 hotspot mutations in high-grade serous ovarian cancers

BACKGROUND: Mutation of TP53 is the most frequent genetic alteration in high-grade serous ovarian cancer (HGSOC). The impact of hotspot mutations of TP53 and protein levels on patient outcomes in HGSOC has not been fully elucidated. METHODS: The study population (n = 791) comprised of HGSOC samples...

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Detalles Bibliográficos
Autores principales: Tuna, Musaffe, Ju, Zhenlin, Yoshihara, Kosuke, Amos, Christopher I., Tanyi, Janos L., Mills, Gordon B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000721/
https://www.ncbi.nlm.nih.gov/pubmed/31780779
http://dx.doi.org/10.1038/s41416-019-0654-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000721/
https://www.ncbi.nlm.nih.gov/pubmed/31780779
http://dx.doi.org/10.1038/s41416-019-0654-8

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