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Clinical relevance of TP53 hotspot mutations in high-grade serous ovarian cancers

BACKGROUND: Mutation of TP53 is the most frequent genetic alteration in high-grade serous ovarian cancer (HGSOC). The impact of hotspot mutations of TP53 and protein levels on patient outcomes in HGSOC has not been fully elucidated. METHODS: The study population (n = 791) comprised of HGSOC samples...

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Detalles Bibliográficos
Autores principales:	Tuna, Musaffe, Ju, Zhenlin, Yoshihara, Kosuke, Amos, Christopher I., Tanyi, Janos L., Mills, Gordon B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000721/ https://www.ncbi.nlm.nih.gov/pubmed/31780779 http://dx.doi.org/10.1038/s41416-019-0654-8

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