Nitric oxide orchestrates metabolic rewiring in M1 macrophages by targeting aconitase 2 and pyruvate dehydrogenase

Profound metabolic changes are characteristic of macrophages during classical activation and have been implicated in this phenotype. Here we demonstrate that nitric oxide (NO) produced by murine macrophages is responsible for TCA cycle alterations and citrate accumulation associated with polarizatio...

Descripción completa

Detalles Bibliográficos
Autores principales: Palmieri, Erika M., Gonzalez-Cotto, Marieli, Baseler, Walter A., Davies, Luke C., Ghesquière, Bart, Maio, Nunziata, Rice, Christopher M., Rouault, Tracey A., Cassel, Teresa, Higashi, Richard M., Lane, Andrew N., Fan, Teresa W.-M., Wink, David A., McVicar, Daniel W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000728/
https://www.ncbi.nlm.nih.gov/pubmed/32019928
http://dx.doi.org/10.1038/s41467-020-14433-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000728/
https://www.ncbi.nlm.nih.gov/pubmed/32019928
http://dx.doi.org/10.1038/s41467-020-14433-7

Ejemplares similares