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TNF-α increases breast cancer stem-like cells through up-regulating TAZ expression via the non-canonical NF-κB pathway
Breast cancer patients often suffer from disease relapse and metastasis due to the presence of breast cancer stem-like cells (BCSCs). Numerous studies have reported that high levels of inflammatory factors, including tumor necrosis factor alpha (TNF-α), promote BCSCs. However, the mechanism by which...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000832/ https://www.ncbi.nlm.nih.gov/pubmed/32019974 http://dx.doi.org/10.1038/s41598-020-58642-y |
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author | Liu, Wenjing Lu, Xiaoqing Shi, Peiguo Yang, Guangxi Zhou, Zhongmei Li, Wei Mao, Xiaoyun Jiang, Dewei Chen, Ceshi |
author_facet | Liu, Wenjing Lu, Xiaoqing Shi, Peiguo Yang, Guangxi Zhou, Zhongmei Li, Wei Mao, Xiaoyun Jiang, Dewei Chen, Ceshi |
author_sort | Liu, Wenjing |
collection | PubMed |
description | Breast cancer patients often suffer from disease relapse and metastasis due to the presence of breast cancer stem-like cells (BCSCs). Numerous studies have reported that high levels of inflammatory factors, including tumor necrosis factor alpha (TNF-α), promote BCSCs. However, the mechanism by which TNF-α promotes BCSCs is unclear. In this study, we demonstrate that TNF-α up-regulates TAZ, a transcriptional co-activator promoting BCSC self-renewal capacity in human breast cancer cell lines. Depletion of TAZ abrogated the increase in BCSCs mediated by TNF-α. TAZ is induced by TNF-α through the non-canonical NF-κB pathway, and our findings suggest that TAZ plays a crucial role in inflammatory factor–promoted breast cancer stemness and could serve as a promising therapeutic target. |
format | Online Article Text |
id | pubmed-7000832 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-70008322020-02-11 TNF-α increases breast cancer stem-like cells through up-regulating TAZ expression via the non-canonical NF-κB pathway Liu, Wenjing Lu, Xiaoqing Shi, Peiguo Yang, Guangxi Zhou, Zhongmei Li, Wei Mao, Xiaoyun Jiang, Dewei Chen, Ceshi Sci Rep Article Breast cancer patients often suffer from disease relapse and metastasis due to the presence of breast cancer stem-like cells (BCSCs). Numerous studies have reported that high levels of inflammatory factors, including tumor necrosis factor alpha (TNF-α), promote BCSCs. However, the mechanism by which TNF-α promotes BCSCs is unclear. In this study, we demonstrate that TNF-α up-regulates TAZ, a transcriptional co-activator promoting BCSC self-renewal capacity in human breast cancer cell lines. Depletion of TAZ abrogated the increase in BCSCs mediated by TNF-α. TAZ is induced by TNF-α through the non-canonical NF-κB pathway, and our findings suggest that TAZ plays a crucial role in inflammatory factor–promoted breast cancer stemness and could serve as a promising therapeutic target. Nature Publishing Group UK 2020-02-04 /pmc/articles/PMC7000832/ /pubmed/32019974 http://dx.doi.org/10.1038/s41598-020-58642-y Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Liu, Wenjing Lu, Xiaoqing Shi, Peiguo Yang, Guangxi Zhou, Zhongmei Li, Wei Mao, Xiaoyun Jiang, Dewei Chen, Ceshi TNF-α increases breast cancer stem-like cells through up-regulating TAZ expression via the non-canonical NF-κB pathway |
title | TNF-α increases breast cancer stem-like cells through up-regulating TAZ expression via the non-canonical NF-κB pathway |
title_full | TNF-α increases breast cancer stem-like cells through up-regulating TAZ expression via the non-canonical NF-κB pathway |
title_fullStr | TNF-α increases breast cancer stem-like cells through up-regulating TAZ expression via the non-canonical NF-κB pathway |
title_full_unstemmed | TNF-α increases breast cancer stem-like cells through up-regulating TAZ expression via the non-canonical NF-κB pathway |
title_short | TNF-α increases breast cancer stem-like cells through up-regulating TAZ expression via the non-canonical NF-κB pathway |
title_sort | tnf-α increases breast cancer stem-like cells through up-regulating taz expression via the non-canonical nf-κb pathway |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000832/ https://www.ncbi.nlm.nih.gov/pubmed/32019974 http://dx.doi.org/10.1038/s41598-020-58642-y |
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