The Replisome Mediates A-NHEJ Repair of Telomeres Lacking POT1-TPP1 Independently of MRN Function

Telomeres use shelterin to protect chromosome ends from activating the DNA damage sensor MRE11-RAD50-NBS1 (MRN), repressing ataxia-telangiectasia, mutated (ATM) and ATM and Rad3-related (ATR) dependent DNA damage checkpoint responses. The MRE11 nuclease is thought to be essential for the resection o...

Descripción completa

Detalles Bibliográficos
Autores principales: Rai, Rekha, Gu, Peili, Broton, Cayla, Kumar-Sinha, Chandan, Chen, Yong, Chang, Sandy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001145/
https://www.ncbi.nlm.nih.gov/pubmed/31825846
http://dx.doi.org/10.1016/j.celrep.2019.11.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001145/
https://www.ncbi.nlm.nih.gov/pubmed/31825846
http://dx.doi.org/10.1016/j.celrep.2019.11.012

Ejemplares similares