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Identification of pAKT as a pharmacodynamic marker for MER kinase in human melanoma G361 cells
BACKGROUND: The MER signaling pathway represents an attractive therapeutic target for human cancers. Growth arrest–specific protein 6 (GAS6)–induced MER phosphorylation is often unstable and difficult to detect without pervanadate pretreatment in human cancer cells, posing a challenge for the develo...
Autores principales: | Chen, Yaoyu, Favata, Margaret, Pusey, Michelle, Li, Jun, Lo, Yvonne, Ye, Min, Wynn, Richard, Wang, Xiaozhao, Yao, Wenqing, Chen, Yingnan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001211/ https://www.ncbi.nlm.nih.gov/pubmed/32042425 http://dx.doi.org/10.1186/s40364-020-0184-9 |
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