Proximity ligation assay reveals both pre- and postsynaptic localization of the APP-processing enzymes ADAM10 and BACE1 in rat and human adult brain

BACKGROUND: Synaptic degeneration and accumulation of amyloid β-peptides (Aβ) are hallmarks of the Alzheimer diseased brain. Aβ is synaptotoxic and produced by sequential cleavage of the amyloid precursor protein (APP) by the β-secretase BACE1 and by γ-secretase. If APP is instead cleaved by the α-s...

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Detalles Bibliográficos
Autores principales: Lundgren, Jolanta L., Vandermeulen, Lina, Sandebring-Matton, Anna, Ahmed, Saheeb, Winblad, Bengt, Di Luca, Monica, Tjernberg, Lars O., Marcello, Elena, Frykman, Susanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001251/
https://www.ncbi.nlm.nih.gov/pubmed/32019490
http://dx.doi.org/10.1186/s12868-020-0554-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001251/
https://www.ncbi.nlm.nih.gov/pubmed/32019490
http://dx.doi.org/10.1186/s12868-020-0554-0

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