Cargando…

Neutrophil-selective deletion of Cxcr2 protects against CNS neurodegeneration in a mouse model of multiple sclerosis

BACKGROUND: Multiple sclerosis (MS) is a chronic debilitating immune-mediated disease of the central nervous system (CNS) driven by demyelination and gray matter neurodegeneration. We previously reported an experimental autoimmune encephalomyelitis (EAE) MS mouse model with elevated serum CXCL1 that...

Descripción completa

Detalles Bibliográficos
Autores principales:	Khaw, Yee Ming, Cunningham, Claire, Tierney, Abigail, Sivaguru, Mayandi, Inoue, Makoto
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001284/ https://www.ncbi.nlm.nih.gov/pubmed/32019585 http://dx.doi.org/10.1186/s12974-020-1730-y

Ejemplares similares

Early-life-trauma triggers interferon-β resistance and neurodegeneration in a multiple sclerosis model via downregulated β1-adrenergic signaling
por: Khaw, Yee Ming, et al.
Publicado: (2021)

Novel Application of Confocal Laser Scanning Microscopy and 3D Volume Rendering toward Improving the Resolution of the Fossil Record of Charcoal
por: Belcher, Claire M., et al.
Publicado: (2013)

Mitochondrial DNA deletions and neurodegeneration in multiple sclerosis
por: Campbell, Graham R, et al.
Publicado: (2011)

Endocytic Mechanism of Internalization of Dietary Peptide Lunasin into Macrophages in Inflammatory Condition Associated with Cardiovascular Disease
por: Cam, Anthony, et al.
Publicado: (2013)

Capturing the Surface Texture and Shape of Pollen: A Comparison of Microscopy Techniques
por: Sivaguru, Mayandi, et al.
Publicado: (2012)

Cofilin Signaling in the CNS Physiology and Neurodegeneration
por: Namme, Jannatun Nayem, et al.
Publicado: (2021)

Second-harmonic patterned polarization-analyzed reflection confocal microscopy of stromal collagen in benign and malignant breast tissues
por: Okoro, Chukwuemeka, et al.
Publicado: (2018)

Early CNS neurodegeneration in radiologically isolated syndrome
por: Azevedo, Christina J., et al.
Publicado: (2015)

The roles of fungus in CNS autoimmune and neurodegeneration disorders
por: Wu, Chuyu, et al.
Publicado: (2023)

Neuronal metabotropic glutamate receptor 8 protects against neurodegeneration in CNS inflammation
por: Woo, Marcel S., et al.
Publicado: (2021)

Light sheet microscopy reveals more gradual light attenuation in light-green versus dark-green soybean leaves
por: Slattery, Rebecca A., et al.
Publicado: (2016)

Exacerbation of CNS inflammation and neurodegeneration by systemic LPS treatment is independent of circulating IL-1β and IL-6
por: Murray, Carol L, et al.
Publicado: (2011)

Serine racemase deletion attenuates neurodegeneration and microvascular damage in diabetic retinopathy
por: Ozaki, Hironori, et al.
Publicado: (2018)

Neurodegeneration in multiple sclerosis
por: Mey, Gabrielle M., et al.
Publicado: (2022)

Enhancing mitochondrial activity in neurons protects against neurodegeneration in a mouse model of multiple sclerosis
por: Rosenkranz, Sina C, et al.
Publicado: (2021)

Sustained Infiltration of Neutrophils Into the CNS Results in Increased Demyelination in a Viral-Induced Model of Multiple Sclerosis
por: Skinner, Dominic D., et al.
Publicado: (2022)

CNS-targeted glucocorticoid reduces pathology in mouse model of amyotrophic lateral sclerosis
por: Evans, Matthew C, et al.
Publicado: (2014)

Decreased CXCR1 and CXCR2 expression on neutrophils in anti-neutrophil cytoplasmic autoantibody-associated vasculitides potentially increases neutrophil adhesion and impairs migration
por: Hu, Nan, et al.
Publicado: (2011)

GeoBioMed perspectives on kidney stone recurrence from the reactive surface area of SWL-derived particles
por: Todorov, Lauren G., et al.
Publicado: (2022)

Extrachromosomal Circular DNA: Current Knowledge and Implications for CNS Aging and Neurodegeneration
por: Ain, Quratul, et al.
Publicado: (2020)

Glymphatic System as a Gateway to Connect Neurodegeneration From Periphery to CNS
por: Natale, Gianfranco, et al.
Publicado: (2021)

Iron and Neurodegeneration in Multiple Sclerosis
por: Khalil, Michael, et al.
Publicado: (2011)

ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis
por: Lemarchant, Sighild, et al.
Publicado: (2016)

Promoting effect of neutrophils on lung tumorigenesis is mediated by CXCR2 and neutrophil elastase
por: Gong, Lei, et al.
Publicado: (2013)

CXCR1 and CXCR2 Inhibition by Ladarixin Improves Neutrophil-Dependent Airway Inflammation in Mice
por: Mattos, Matheus Silverio, et al.
Publicado: (2020)

Deletion of caspase-8 in mouse myeloid cells blocks microglia pro-inflammatory activation and confers protection in MPTP neurodegeneration model
por: Kavanagh, Edel, et al.
Publicado: (2015)

Meta-analysis of mouse transcriptomic studies supports a context-dependent astrocyte reaction in acute CNS injury versus neurodegeneration
por: Das, Sudeshna, et al.
Publicado: (2020)

Adapting tissue-engineered in vitro CNS models for high-throughput study of neurodegeneration
por: O’Rourke, Caitriona, et al.
Publicado: (2017)

Travertine crystal growth ripples record the hydraulic history of ancient Rome’s Anio Novus aqueduct
por: Keenan-Jones, Duncan, et al.
Publicado: (2022)

CXCR4 and CXCR7 Inhibition Ameliorates the Formation of Platelet–Neutrophil Complexes and Neutrophil Extracellular Traps through Adora2b Signaling
por: Ngamsri, Kristian-Christos, et al.
Publicado: (2021)

Erratum to: ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis
por: Lemarchant, Sighild, et al.
Publicado: (2016)

Mitochondrial dysfunction and neurodegeneration in multiple sclerosis
por: Su, Kimmy, et al.
Publicado: (2013)

Iron and neurodegeneration in the multiple sclerosis brain
por: Hametner, Simon, et al.
Publicado: (2013)

Microbiome-mediated neutrophil recruitment via CXCR2 and protection from amebic colitis
por: Watanabe, Koji, et al.
Publicado: (2017)

CREB1-driven CXCR4(hi) neutrophils promote skin inflammation in mouse models and human patients
por: Chen, Jiaoling, et al.
Publicado: (2023)

Feline Immunodeficiency Virus Neuropathogenesis: A Model for HIV-Induced CNS Inflammation and Neurodegeneration
por: Meeker, Rick B., et al.
Publicado: (2017)

CXCR4, the master regulator of neutrophil trafficking in homeostasis and disease
por: De Filippo, Katia, et al.
Publicado: (2018)

CXCR2 intrinsically drives the maturation and function of neutrophils in mice
por: Delobel, Pauline, et al.
Publicado: (2022)

Assessment of Arf6 Deletion in PLB-985 Differentiated in Neutrophil-Like Cells and in Mouse Neutrophils: Impact on Adhesion and Migration
por: Gamara, Jouda, et al.
Publicado: (2020)

CXCR4(hi) effector neutrophils in sickle cell anemia: potential role for elevated circulating serotonin (5-HT) in CXCR4(hi) neutrophil polarization
por: Garcia, Flavia, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_8vlceltfojtll3japat8g1est7