Tau-tubulin kinase 1 and amyloid-β peptide induce phosphorylation of collapsin response mediator protein-2 and enhance neurite degeneration in Alzheimer disease mouse models

The accumulation of phosphorylated tau protein (pTau) in the entorhinal cortex (EC) is the earliest tau pathology in Alzheimer’s disease (AD). Tau tubulin kinase-1 (TTBK1) is a neuron-specific tau kinase and expressed in the EC and hippocampal regions in both human and mouse brains. Here we report t...

Descripción completa

Detalles Bibliográficos
Autores principales: Ikezu, Seiko, Ingraham Dixie, Kaitlin L., Koro, Lacin, Watanabe, Takashi, Kaibuchi, Kozo, Ikezu, Tsuneya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001309/
https://www.ncbi.nlm.nih.gov/pubmed/32019603
http://dx.doi.org/10.1186/s40478-020-0890-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001309/
https://www.ncbi.nlm.nih.gov/pubmed/32019603
http://dx.doi.org/10.1186/s40478-020-0890-4

Ejemplares similares