Structural Insights into the Unique Activation Mechanisms of a Non-classical Calpain and Its Disease-Causing Variants

Increased calpain activity is linked to neuroinflammation including a heritable retinal disease caused by hyper-activating mutations in the calcium-activated calpain-5 (CAPN5) protease. Although structures for classical calpains are known, the structure of CAPN5, a non-classical calpain, remains und...

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Detalles Bibliográficos
Autores principales: Velez, Gabriel, Sun, Young Joo, Khan, Saif, Yang, Jing, Herrmann, Jonathan, Chemudupati, Teja, MacLaren, Robert E., Gakhar, Lokesh, Wakatsuki, Soichi, Bassuk, Alexander G., Mahajan, Vinit B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001764/
https://www.ncbi.nlm.nih.gov/pubmed/31968260
http://dx.doi.org/10.1016/j.celrep.2019.12.077

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001764/
https://www.ncbi.nlm.nih.gov/pubmed/31968260
http://dx.doi.org/10.1016/j.celrep.2019.12.077

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