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Neutralization of pertussis toxin by a single antibody prevents clinical pertussis in neonatal baboons
Pertussis continues to cause considerable infant mortality world-wide, which could be addressed in part by passive immunization strategies. Antibody hu1B7 is a candidate therapeutic that potently neutralizes pertussis toxin in vitro, prevents leukocytosis in mice and treats established disease in we...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Association for the Advancement of Science
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002138/ https://www.ncbi.nlm.nih.gov/pubmed/32076653 http://dx.doi.org/10.1126/sciadv.aay9258 |