Visualizing locus-specific sister chromatid exchange reveals differential patterns of replication stress-induced fragile site breakage

Chromosomal fragile sites are genomic loci sensitive to replication stress which accumulate high levels of DNA damage, and are frequently mutated in cancers. Fragile site damage is thought to arise from the aberrant repair of spontaneous replication stress, however successful fragile site repair can...

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Detalles Bibliográficos
Autores principales: Waisertreiger, Irina, Popovich, Katherine, Block, Maya, Anderson, Krista R., Barlow, Jacqueline H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002298/
https://www.ncbi.nlm.nih.gov/pubmed/31636383
http://dx.doi.org/10.1038/s41388-019-1054-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002298/
https://www.ncbi.nlm.nih.gov/pubmed/31636383
http://dx.doi.org/10.1038/s41388-019-1054-5

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