Cargando…

Reducing Aspergillus fumigatus Virulence through Targeted Dysregulation of the Conidiation Pathway

Inhalation of conidia of the opportunistic mold Aspergillus fumigatus by immunocompromised hosts can lead to invasive pulmonary disease. Inhaled conidia that escape immune defenses germinate to form filamentous hyphae that invade lung tissues. Conidiation rarely occurs during invasive infection of t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Stewart, James I. P., Fava, Vinicius M., Kerkaert, Joshua D., Subramanian, Adithya S., Gravelat, Fabrice N., Lehoux, Melanie, Howell, P. Lynne, Cramer, Robert A., Sheppard, Donald C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002347/ https://www.ncbi.nlm.nih.gov/pubmed/32019801 http://dx.doi.org/10.1128/mBio.03202-19

Ejemplares similares

Assembly and disassembly of Aspergillus fumigatus conidial rodlets
por: Valsecchi, Isabel, et al.
Publicado: (2019)

What Are the Functions of Chitin Deacetylases in Aspergillus fumigatus?
por: Mouyna, Isabelle, et al.
Publicado: (2020)

An Ssd1 Homolog Impacts Trehalose and Chitin Biosynthesis and Contributes to Virulence in Aspergillus fumigatus
por: Thammahong, Arsa, et al.
Publicado: (2019)

A Conserved C-Terminal Domain of the Aspergillus fumigatus Developmental Regulator MedA Is Required for Nuclear Localization, Adhesion and Virulence
por: Al Abdallah, Qusai, et al.
Publicado: (2012)

Co-Operative Biofilm Interactions between Aspergillus fumigatus and Pseudomonas aeruginosa through Secreted Galactosaminogalactan Exopolysaccharide
por: Ostapska, Hanna, et al.
Publicado: (2022)

An Alanine Aminotransferase Is Required for Biofilm-Specific Resistance of Aspergillus fumigatus to Echinocandin Treatment
por: Kerkaert, Joshua D., et al.
Publicado: (2022)

Disruption of the Aspergillus fumigatus RNA interference machinery alters the conidial transcriptome
por: Kelani, Abdulrahman A., et al.
Publicado: (2023)

Proteome Analysis Reveals the Conidial Surface Protein CcpA Essential for Virulence of the Pathogenic Fungus Aspergillus fumigatus
por: Voltersen, Vera, et al.
Publicado: (2018)

Aspergillus fumigatus biofilms: Toward understanding how growth as a multicellular network increases antifungal resistance and disease progression
por: Morelli, Kaesi A., et al.
Publicado: (2021)

Use of a human small airway epithelial cell line to study the interactions of Aspergillus fumigatus with pulmonary epithelial cells
por: Liu, Hong, et al.
Publicado: (2023)

The Role of RodA-Conserved Cysteine Residues in the Aspergillus fumigatus Conidial Surface Organization
por: Valsecchi, Isabel, et al.
Publicado: (2020)

Conidial Dihydroxynaphthalene Melanin of the Human Pathogenic Fungus Aspergillus fumigatus Interferes with the Host Endocytosis Pathway
por: Thywißen, Andreas, et al.
Publicado: (2011)

Conidiation Color Mutants of Aspergillus fumigatus Are Highly Pathogenic to the Heterologous Insect Host Galleria mellonella
por: Jackson, Jennifer C., et al.
Publicado: (2009)

Conidial Melanin of the Human-Pathogenic Fungus Aspergillus fumigatus Disrupts Cell Autonomous Defenses in Amoebae
por: Ferling, Iuliia, et al.
Publicado: (2020)

A phylogenetic approach to explore the Aspergillus fumigatus conidial surface-associated proteome and its role in pathogenesis
por: Goldman, Gustavo, et al.
Publicado: (2023)

Temperature during conidiation affects stress tolerance, pigmentation, and trypacidin accumulation in the conidia of the airborne pathogen Aspergillus fumigatus
por: Hagiwara, Daisuke, et al.
Publicado: (2017)

Solid-state NMR molecular snapshots of Aspergillus fumigatus cell wall architecture during a conidial morphotype transition
por: Lamon, Gaëlle, et al.
Publicado: (2023)

RbdB, a Rhomboid Protease Critical for SREBP Activation and Virulence in Aspergillus fumigatus
por: Dhingra, Sourabh, et al.
Publicado: (2016)

Iron – A Key Nexus in the Virulence of Aspergillus fumigatus
por: Haas, Hubertus
Publicado: (2012)

Urease of Aspergillus fumigatus Is Required for Survival in Macrophages and Virulence
por: Xiong, Zhenzhen, et al.
Publicado: (2023)

The IL-1 Receptor Is Required to Maintain Neutrophil Viability and Function During Aspergillus fumigatus Airway Infection
por: Ralph, Benjamin AWR, et al.
Publicado: (2021)

Heterogeneity among Isolates Reveals that Fitness in Low Oxygen Correlates with Aspergillus fumigatus Virulence
por: Kowalski, Caitlin H., et al.
Publicado: (2016)

Development stage-specific proteomic profiling uncovers small, lineage specific proteins most abundant in the Aspergillus Fumigatus conidial proteome
por: Suh, Moo-Jin, et al.
Publicado: (2012)

The DmtA methyltransferase contributes to Aspergillus flavus conidiation, sclerotial production, aflatoxin biosynthesis and virulence
por: Yang, Kunlong, et al.
Publicado: (2016)

The Influence of Genetic Stability on Aspergillus fumigatus Virulence and Azole Resistance
por: dos Reis, Thaila Fernanda, et al.
Publicado: (2017)

The Lysine Deacetylase RpdA Is Essential for Virulence in Aspergillus fumigatus
por: Bauer, Ingo, et al.
Publicado: (2019)

Aspergillus fumigatus Acetate Utilization Impacts Virulence Traits and Pathogenicity
por: Ries, Laure Nicolas Annick, et al.
Publicado: (2021)

Aspergillus fumigatus versus Genus Aspergillus: Conservation, Adaptive Evolution and Specific Virulence Genes
por: Gupta, Shishir K., et al.
Publicado: (2021)

Deletion of the α-(1,3)-Glucan Synthase Genes Induces a Restructuring of the Conidial Cell Wall Responsible for the Avirulence of Aspergillus fumigatus
por: Beauvais, Anne, et al.
Publicado: (2013)

NikA/TcsC Histidine Kinase Is Involved in Conidiation, Hyphal Morphology, and Responses to Osmotic Stress and Antifungal Chemicals in Aspergillus fumigatus
por: Hagiwara, Daisuke, et al.
Publicado: (2013)

Structural and biochemical characterization of the exopolysaccharide deacetylase Agd3 required for Aspergillus fumigatus biofilm formation
por: Bamford, Natalie C., et al.
Publicado: (2020)

Aspergillus fumigatus Strain-Specific Conidia Lung Persistence Causes an Allergic Broncho-Pulmonary Aspergillosis-Like Disease Phenotype
por: Jones, Jane T., et al.
Publicado: (2021)

Understanding the Role of Nitronate Monooxygenases in Virulence of the Human Fungal Pathogen Aspergillus fumigatus
por: Nguyen, Phuong Tuyen, et al.
Publicado: (2022)

Galectin-3 enhances neutrophil motility and extravasation into the airways during Aspergillus fumigatus infection
por: Snarr, Brendan D., et al.
Publicado: (2020)

Siderophore Biosynthesis But Not Reductive Iron Assimilation Is Essential for Aspergillus fumigatus Virulence
por: Schrettl, Markus, et al.
Publicado: (2004)

Aspergillus fumigatus melanins: interference with the host endocytosis pathway and impact on virulence
por: Heinekamp, Thorsten, et al.
Publicado: (2013)

rtfA controls development, secondary metabolism, and virulence in Aspergillus fumigatus
por: Myers, Ryan R., et al.
Publicado: (2017)

2599. Studying the Effects of Altering Histone Modification on Aspergillus fumigatus Virulence
por: Lee, Pam, et al.
Publicado: (2019)

Arginine Auxotrophy Affects Siderophore Biosynthesis and Attenuates Virulence of Aspergillus fumigatus
por: Dietl, Anna-Maria, et al.
Publicado: (2020)

Pseudomonas aeruginosa Virulence Factors Support Voriconazole Effects on Aspergillus fumigatus
por: Sass, Gabriele, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_t21cv22q8qt1ghborh2vgnqnl4