CD44 Loss Disrupts Lung Lipid Surfactant Homeostasis and Exacerbates Oxidized Lipid-Induced Lung Inflammation

Alveolar macrophages (AMs) are CD44 expressing cells that reside in the alveolar space where they maintain lung homeostasis by serving critical roles in immunosurveillance and lipid surfactant catabolism. AMs lacking CD44 are unable to bind the glycosaminoglycan, hyaluronan, which compromises their...

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Detalles Bibliográficos
Autores principales: Dong, Yifei, Arif, Arif A., Guo, Jian, Ha, Zongyi, Lee-Sayer, Sally S. M., Poon, Grace F. T., Dosanjh, Manisha, Roskelley, Calvin D., Huan, Tao, Johnson, Pauline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002364/
https://www.ncbi.nlm.nih.gov/pubmed/32082314
http://dx.doi.org/10.3389/fimmu.2020.00029

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002364/
https://www.ncbi.nlm.nih.gov/pubmed/32082314
http://dx.doi.org/10.3389/fimmu.2020.00029

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