Synthetic analogues of 2-oxo acids discriminate metabolic contribution of the 2-oxoglutarate and 2-oxoadipate dehydrogenases in mammalian cells and tissues

The biological significance of the DHTKD1-encoded 2-oxoadipate dehydrogenase (OADH) remains obscure due to its catalytic redundancy with the ubiquitous OGDH-encoded 2-oxoglutarate dehydrogenase (OGDH). In this work, metabolic contributions of OADH and OGDH are discriminated by exposure of cells/tiss...

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Detalles Bibliográficos
Autores principales: Artiukhov, Artem V., Grabarska, Aneta, Gumbarewicz, Ewelina, Aleshin, Vasily A., Kähne, Thilo, Obata, Toshihiro, Kazantsev, Alexey V., Lukashev, Nikolay V., Stepulak, Andrzej, Fernie, Alisdair R., Bunik, Victoria I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002488/
https://www.ncbi.nlm.nih.gov/pubmed/32024885
http://dx.doi.org/10.1038/s41598-020-58701-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002488/
https://www.ncbi.nlm.nih.gov/pubmed/32024885
http://dx.doi.org/10.1038/s41598-020-58701-4

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