Cargando…

Synthetic analogues of 2-oxo acids discriminate metabolic contribution of the 2-oxoglutarate and 2-oxoadipate dehydrogenases in mammalian cells and tissues

The biological significance of the DHTKD1-encoded 2-oxoadipate dehydrogenase (OADH) remains obscure due to its catalytic redundancy with the ubiquitous OGDH-encoded 2-oxoglutarate dehydrogenase (OGDH). In this work, metabolic contributions of OADH and OGDH are discriminated by exposure of cells/tiss...

Descripción completa

Detalles Bibliográficos
Autores principales:	Artiukhov, Artem V., Grabarska, Aneta, Gumbarewicz, Ewelina, Aleshin, Vasily A., Kähne, Thilo, Obata, Toshihiro, Kazantsev, Alexey V., Lukashev, Nikolay V., Stepulak, Andrzej, Fernie, Alisdair R., Bunik, Victoria I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002488/ https://www.ncbi.nlm.nih.gov/pubmed/32024885 http://dx.doi.org/10.1038/s41598-020-58701-4

Ejemplares similares

Selective Inhibition of 2-Oxoglutarate and 2-Oxoadipate Dehydrogenases by the Phosphonate Analogs of Their 2-Oxo Acid Substrates
por: Artiukhov, Artem V., et al.
Publicado: (2021)

Administration of Phosphonate Inhibitors of Dehydrogenases of 2-Oxoglutarate and 2-Oxoadipate to Rats Elicits Target-Specific Metabolic and Physiological Responses
por: Bunik, Victoria I., et al.
Publicado: (2022)

Delayed Impact of 2-Oxoadipate Dehydrogenase Inhibition on the Rat Brain Metabolism Is Linked to Protein Glutarylation
por: Boyko, Alexandra I., et al.
Publicado: (2022)

Increasing Inhibition of the Rat Brain 2-Oxoglutarate Dehydrogenase Decreases Glutathione Redox State, Elevating Anxiety and Perturbing Stress Adaptation
por: Artiukhov, Artem V., et al.
Publicado: (2022)

Inhibition of mitochondrial 2-oxoglutarate dehydrogenase impairs viability of cancer cells in a cell-specific metabolism-dependent manner
por: Bunik, Victoria I., et al.
Publicado: (2016)

Mitochondrial Impairment May Increase Cellular NAD(P)H: Resazurin Oxidoreductase Activity, Perturbing the NAD(P)H-Based Viability Assays
por: Aleshin, Vasily A., et al.
Publicado: (2015)

Phosphonate Inhibitors of Pyruvate Dehydrogenase Perturb Homeostasis of Amino Acids and Protein Succinylation in the Brain
por: Artiukhov, Artem V., et al.
Publicado: (2022)

Daytime Dependence of the Activity of the Rat Brain Pyruvate Dehydrogenase Corresponds to the Mitochondrial Sirtuin 3 Level and Acetylation of Brain Proteins, All Regulated by Thiamine Administration Decreasing Phosphorylation of PDHA Ser293
por: Aleshin, Vasily A., et al.
Publicado: (2021)

Interplay Between Thiamine and p53/p21 Axes Affects Antiproliferative Action of Cisplatin in Lung Adenocarcinoma Cells by Changing Metabolism of 2-Oxoglutarate/Glutamate
por: Aleshin, Vasily A., et al.
Publicado: (2021)

Specific inhibition by synthetic analogs of pyruvate reveals that the pyruvate dehydrogenase reaction is essential for metabolism and viability of glioblastoma cells
por: Bunik, Victoria I., et al.
Publicado: (2015)

Multiple Forms of Glutamate Dehydrogenase in Animals: Structural Determinants and Physiological Implications
por: Bunik, Victoria, et al.
Publicado: (2016)

Phosphonate Analogs of 2-Oxoglutarate Perturb Metabolism and Gene Expression in Illuminated Arabidopsis Leaves
por: Araújo, Wagner L., et al.
Publicado: (2012)

Activation of Mitochondrial 2-Oxoglutarate Dehydrogenase by Cocarboxylase in Human Lung Adenocarcinoma Cells A549 Is p53/p21-Dependent and Impairs Cellular Redox State, Mimicking the Cisplatin Action
por: Bunik, Victoria I., et al.
Publicado: (2020)

Behavioral Impact of the Regulation of the Brain 2-Oxoglutarate Dehydrogenase Complex by Synthetic Phosphonate Analog of 2-Oxoglutarate: Implications into the Role of the Complex in Neurodegenerative Diseases
por: Trofimova, L., et al.
Publicado: (2010)

Investigation into the Mode of Phosphate Activation in the 4-Hydroxy-4-Methyl-2-Oxoglutarate/4-Carboxy-4-Hydroxy-2-Oxoadipate Aldolase from Pseudomonas putida F1
por: Mazurkewich, Scott, et al.
Publicado: (2016)

The Brain Protein Acylation System Responds to Seizures in the Rat Model of PTZ-Induced Epilepsy
por: Zavileyskiy, Lev G., et al.
Publicado: (2022)

Assessment of Interactions between Cisplatin and Two Histone Deacetylase Inhibitors in MCF7, T47D and MDA-MB-231 Human Breast Cancer Cell Lines – An Isobolographic Analysis
por: Wawruszak, Anna, et al.
Publicado: (2015)

Acute Prenatal Hypoxia in Rats Affects Physiology and Brain Metabolism in the Offspring, Dependent on Sex and Gestational Age
por: Graf, Anastasia V., et al.
Publicado: (2022)

Inhibition of 2-Oxoglutarate Dehydrogenase as a Chemical Model of Acute Hypobaric Hypoxia
por: Graf, Anastasia, et al.
Publicado: (2021)

2-Oxoglutarate: linking TCA cycle function with amino acid, glucosinolate, flavonoid, alkaloid, and gibberellin biosynthesis
por: Araújo, Wagner L., et al.
Publicado: (2014)

Pentylenetetrazole-Induced Seizures Are Increased after Kindling, Exhibiting Vitamin-Responsive Correlations to the Post-Seizures Behavior, Amino Acids Metabolism and Key Metabolic Regulators in the Rat Brain
por: Aleshin, Vasily A., et al.
Publicado: (2023)

Directed Evolution of (R)-2-Hydroxyglutarate Dehydrogenase Improves 2-Oxoadipate Reduction by 2 Orders of Magnitude
por: Saez-Jimenez, Veronica, et al.
Publicado: (2022)

Histone Deacetylase Inhibitor SAHA as Potential Targeted Therapy Agent for Larynx Cancer Cells
por: Grabarska, Aneta, et al.
Publicado: (2017)

Preparation of Affinity Purified Antibodies against ε-Glutaryl-Lysine Residues in Proteins for Investigation of Glutarylated Proteins in Animal Tissues
por: Artiukhov, Artem V., et al.
Publicado: (2021)

Probing the E1o-E2o and E1a-E2o Interactions in Binary Subcomplexes of the Human 2-Oxoglutarate Dehydrogenase and 2-Oxoadipate Dehydrogenase Complexes by Chemical Cross-Linking Mass Spectrometry and Molecular Dynamics Simulation
por: Ozohanics, Oliver, et al.
Publicado: (2023)

Physiological and Biochemical Markers of the Sex-Specific Sensitivity to Epileptogenic Factors, Delayed Consequences of Seizures and Their Response to Vitamins B1 and B6 in a Rat Model
por: Aleshin, Vasily A., et al.
Publicado: (2021)

The use of metabolomics to dissect plant responses to abiotic stresses
por: Obata, Toshihiro, et al.
Publicado: (2012)

Downregulation of the E(2) Subunit of 2-Oxoglutarate Dehydrogenase Modulates Plant Growth by Impacting Carbon–Nitrogen Metabolism in Arabidopsis thaliana
por: Condori-Apfata, Jorge A, et al.
Publicado: (2021)

Severe Spinal Cord Injury in Rats Induces Chronic Changes in the Spinal Cord and Cerebral Cortex Metabolism, Adjusted by Thiamine That Improves Locomotor Performance
por: Boyko, Alexandra, et al.
Publicado: (2021)

ABHD11 maintains 2-oxoglutarate metabolism by preserving functional lipoylation of the 2-oxoglutarate dehydrogenase complex
por: Bailey, Peter S. J., et al.
Publicado: (2020)

Oxoglutarate dehydrogenase complex controls glutamate-mediated neuronal death
por: Weidinger, Adelheid, et al.
Publicado: (2023)

The Central Carbon and Energy Metabolism of Marine Diatoms
por: Obata, Toshihiro, et al.
Publicado: (2013)

Inhibition of JMJD6 by 2‐Oxoglutarate Mimics
por: Islam, Md. Sailful, et al.
Publicado: (2021)

Functional Versatility of the Human 2-Oxoadipate Dehydrogenase in the L-Lysine Degradation Pathway toward Its Non-Cognate Substrate 2-Oxopimelic Acid
por: Nemeria, Natalia S., et al.
Publicado: (2022)

Detailed kinetics and regulation of mammalian 2-oxoglutarate dehydrogenase
por: Qi, Feng, et al.
Publicado: (2011)

2-Oxoglutarate-dependent dioxygenases in the biosynthesis of simple coumarins
por: Shimizu, Bun-Ichi
Publicado: (2014)

Protein Hydroxylation Catalyzed by 2-Oxoglutarate-dependent Oxygenases
por: Markolovic, Suzana, et al.
Publicado: (2015)

Zingiber officinale Rosc. in the Treatment of Metabolic Syndrome Disorders—A Review of In Vivo Studies
por: Gumbarewicz, Ewelina, et al.
Publicado: (2022)

Metabolite pools and carbon flow during C(4) photosynthesis in maize: (13)CO(2) labeling kinetics and cell type fractionation
por: Arrivault, Stéphanie, et al.
Publicado: (2017)

Structural Basis for the Binding of Allosteric Activators Leucine and ADP to Mammalian Glutamate Dehydrogenase
por: Aleshin, Vasily A., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_u402tdpq6cai1sd20pkaqn9ssq