High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations

The impact of somatic structural variants (SVs) on gene expression in cancer is largely unknown. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole-genome sequencing data and RNA sequencing from a common set of 1220 cancer cases, we report...

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Detalles Bibliográficos
Autores principales: Zhang, Yiqun, Chen, Fengju, Fonseca, Nuno A., He, Yao, Fujita, Masashi, Nakagawa, Hidewaki, Zhang, Zemin, Brazma, Alvis, Creighton, Chad J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002524/
https://www.ncbi.nlm.nih.gov/pubmed/32024823
http://dx.doi.org/10.1038/s41467-019-13885-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002524/
https://www.ncbi.nlm.nih.gov/pubmed/32024823
http://dx.doi.org/10.1038/s41467-019-13885-w

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