Inferring structural variant cancer cell fraction

We present SVclone, a computational method for inferring the cancer cell fraction of structural variant (SV) breakpoints from whole-genome sequencing data. SVclone accurately determines the variant allele frequencies of both SV breakends, then simultaneously estimates the cancer cell fraction and SV...

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Detalles Bibliográficos
Autores principales: Cmero, Marek, Yuan, Ke, Ong, Cheng Soon, Schröder, Jan, Corcoran, Niall M., Papenfuss, Tony, Hovens, Christopher M., Markowetz, Florian, Macintyre, Geoff
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002525/
https://www.ncbi.nlm.nih.gov/pubmed/32024845
http://dx.doi.org/10.1038/s41467-020-14351-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002525/
https://www.ncbi.nlm.nih.gov/pubmed/32024845
http://dx.doi.org/10.1038/s41467-020-14351-8

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