Implementation of a Physiologically Based Pharmacokinetic Modeling Approach to Guide Optimal Dosing Regimens for Imatinib and Potential Drug Interactions in Paediatrics

Long-term use of imatinib is effective and well-tolerated in children with chronic myeloid leukaemia (CML) yet defining an optimal dosing regimen for imatinib in younger patients is a challenge. The potential interactions between imatinib and coadministered drugs in this “special” population also re...

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Detalles Bibliográficos
Autores principales: Adiwidjaja, Jeffry, Boddy, Alan V., McLachlan, Andrew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002565/
https://www.ncbi.nlm.nih.gov/pubmed/32082165
http://dx.doi.org/10.3389/fphar.2019.01672

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002565/
https://www.ncbi.nlm.nih.gov/pubmed/32082165
http://dx.doi.org/10.3389/fphar.2019.01672

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