High-throughput identification of synthetic riboswitches by barcode-free amplicon-sequencing in human cells

Synthetic riboswitches mediating ligand-dependent RNA cleavage or splicing-modulation represent elegant tools to control gene expression in various applications, including next-generation gene therapy. However, due to the limited understanding of context-dependent structure–function relationships, t...

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Detalles Bibliográficos
Autores principales: Strobel, Benjamin, Spöring, Maike, Klein, Holger, Blazevic, Dragica, Rust, Werner, Sayols, Sergi, Hartig, Jörg S., Kreuz, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002664/
https://www.ncbi.nlm.nih.gov/pubmed/32024835
http://dx.doi.org/10.1038/s41467-020-14491-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002664/
https://www.ncbi.nlm.nih.gov/pubmed/32024835
http://dx.doi.org/10.1038/s41467-020-14491-x

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