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Discovery of Lonafarnib-Like Compounds: Pharmacophore Modeling and Molecular Dynamics Studies

[Image: see text] Progeria is a globally noticed rare genetic disorder manifested by premature aging with no effective treatment. Under these circumstances, farnesyltransferase inhibitors (FTIs) are marked as promising drug candidates. Correspondingly, a pharmacophore model was generated exploiting...

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Detalles Bibliográficos
Autores principales:	Rampogu, Shailima, Baek, Ayoung, Son, Minky, Park, Chanin, Yoon, Sanghwa, Parate, Shraddha, Lee, Keun Woo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2020
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003205/ https://www.ncbi.nlm.nih.gov/pubmed/32039312 http://dx.doi.org/10.1021/acsomega.9b02263

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