Local delivery of minocycline-loaded PLGA nanoparticles from gelatin-coated neural implants attenuates acute brain tissue responses in mice

BACKGROUND: Neural interfaces often elicit inflammatory responses and neuronal loss in the surrounding tissue which adversely affect the function and longevity of the implanted device. Minocycline, an anti-inflammatory pharmaceutics with neuroprotective properties, may be used for reducing the acute...

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Detalles Bibliográficos
Autores principales: Holmkvist, Alexander Dontsios, Agorelius, Johan, Forni, Matilde, Nilsson, Ulf J., Linsmeier, Cecilia Eriksson, Schouenborg, Jens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003334/
https://www.ncbi.nlm.nih.gov/pubmed/32024534
http://dx.doi.org/10.1186/s12951-020-0585-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003334/
https://www.ncbi.nlm.nih.gov/pubmed/32024534
http://dx.doi.org/10.1186/s12951-020-0585-9

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