Cargando…

Local delivery of minocycline-loaded PLGA nanoparticles from gelatin-coated neural implants attenuates acute brain tissue responses in mice

BACKGROUND: Neural interfaces often elicit inflammatory responses and neuronal loss in the surrounding tissue which adversely affect the function and longevity of the implanted device. Minocycline, an anti-inflammatory pharmaceutics with neuroprotective properties, may be used for reducing the acute...

Descripción completa

Detalles Bibliográficos
Autores principales:	Holmkvist, Alexander Dontsios, Agorelius, Johan, Forni, Matilde, Nilsson, Ulf J., Linsmeier, Cecilia Eriksson, Schouenborg, Jens
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003334/ https://www.ncbi.nlm.nih.gov/pubmed/32024534 http://dx.doi.org/10.1186/s12951-020-0585-9

Ejemplares similares

An array of highly flexible electrodes with a tailored configuration locked by gelatin during implantation—initial evaluation in cortex cerebri of awake rats
por: Agorelius, Johan, et al.
Publicado: (2015)

Influence of Probe Flexibility and Gelatin Embedding on Neuronal Density and Glial Responses to Brain Implants
por: Köhler, Per, et al.
Publicado: (2015)

The density difference between tissue and neural probes is a key factor for glial scarring
por: Lind, Gustav, et al.
Publicado: (2013)

Minocycline-loaded PLGA electrospun membrane prevents alveolar bone loss in experimental peridontitis
por: Ma, Yihui, et al.
Publicado: (2020)

Implant Size and Fixation Mode Strongly Influence Tissue Reactions in the CNS
por: Thelin, Jonas, et al.
Publicado: (2011)

Impact of degradable nanowires on long-term brain tissue responses
por: Gällentoft, Lina, et al.
Publicado: (2016)

Improved drug loading and antibacterial activity of minocycline-loaded PLGA nanoparticles prepared by solid/oil/water ion pairing method
por: Kashi, Tahereh Sadat Jafarzadeh, et al.
Publicado: (2012)

3D microelectrode cluster and stimulation paradigm yield powerful analgesia without noticeable adverse effects
por: Forni, Matilde, et al.
Publicado: (2021)

Multiple-Coated PLGA Nanoparticles Loading Triptolide Attenuate Injury of a Cellular Model of Alzheimer's Disease
por: Jia, Lu, et al.
Publicado: (2021)

Bioactive Ibuprofen-Loaded PLGA Coatings for Multifunctional Surface Modification of Medical Devices
por: Gherasim, Oana, et al.
Publicado: (2021)

Paclitaxel-Loaded PLGA Coating Stents in the Treatment of Benign Cicatrical Airway Stenosis
por: Qiu, Xiaojian, et al.
Publicado: (2022)

Gefitinib loaded PLGA and chitosan coated PLGA nanoparticles with magnified cytotoxicity against A549 lung cancer cell lines
por: Alshetaili, Abdullah S.
Publicado: (2021)

Minocycline Attenuates Experimental Subarachnoid Hemorrhage in Rats
por: Li, Jingbo, et al.
Publicado: (2019)

PLGA Microspheres Incorporated Gelatin Scaffold: Microspheres Modulate Scaffold Properties
por: Banerjee, Indranil, et al.
Publicado: (2009)

PLGA Membranes Functionalized with Gelatin through Biomimetic Mussel-Inspired Strategy
por: Carmagnola, Irene, et al.
Publicado: (2020)

Mesenchymal Stem Cells Loaded with Gelatin Microcryogels Attenuate Renal Fibrosis
por: Geng, Xiaodong, et al.
Publicado: (2019)

PEG 400:Trehalose Coating Enhances Curcumin-Loaded PLGA Nanoparticle Internalization in Neuronal Cells
por: Caballero-Florán, Isaac H., et al.
Publicado: (2023)

HA-Coated PLGA Nanoparticles Loaded with Apigenin for Colon Cancer with High Expression of CD44
por: Yang, Bo, et al.
Publicado: (2023)

Protein Loading into Spongelike PLGA Microspheres
por: Kim, Yuyoung, et al.
Publicado: (2021)

Biophysical analysis of gelatin and PLGA nanoparticle interactions with complex biomimetic lung surfactant models
por: Daear, W., et al.
Publicado: (2022)

Evaluation of Cell Proliferation and Wound Healing Effects of Vitamin A Palmitate-Loaded PLGA/Chitosan-Coated PLGA Nanoparticles: Preparation, Characterization, Release, and Release Kinetics
por: Baghirova, Lala, et al.
Publicado: (2023)

Investigation of a Minocycline-Loaded Nanoemulgel for the Treatment of Acne Rosacea
por: Siddiqui, Ayesha, et al.
Publicado: (2022)

Rhynchophylline Loaded-mPEG-PLGA Nanoparticles Coated with Tween-80 for Preliminary Study in Alzheimer’s Disease
por: Xu, Ruiling, et al.
Publicado: (2020)

Chitosan-Coated PLGA Nanoparticles Loaded with Peganum harmala Alkaloids with Promising Antibacterial and Wound Healing Activities
por: Azzazy, Hassan Mohamed El-Said, et al.
Publicado: (2021)

Gold Half-Shell-Coated Paclitaxel-Loaded PLGA Nanoparticles for the Targeted Chemo-Photothermal Treatment of Cancer
por: Ibarra, Jaime, et al.
Publicado: (2023)

Docetaxel-loaded PLGA and PLGA-PEG nanoparticles for intravenous application: pharmacokinetics and biodistribution profile
por: Rafiei, Pedram, et al.
Publicado: (2017)

Reduced Cardiotoxicity of Ponatinib-Loaded PLGA-PEG-PLGA Nanoparticles in Zebrafish Xenograft Model
por: Al-Thani, Hissa F., et al.
Publicado: (2022)

Minocycline Attenuates Microglia/Macrophage Phagocytic Activity and Inhibits SAH-Induced Neuronal Cell Death and Inflammation
por: Blecharz-Lang, Kinga G., et al.
Publicado: (2022)

Cannabinoid derivate-loaded PLGA nanocarriers for oral administration: formulation, characterization, and cytotoxicity studies
por: Martín-Banderas, Lucía, et al.
Publicado: (2012)

Microfluidic-Based Formulation of Essential Oils-Loaded Chitosan Coated PLGA Particles Enhances Their Bioavailability and Nematocidal Activity
por: Helal, Mohamed A., et al.
Publicado: (2022)

Composite PLGA–Nanobioceramic Coating on Moxifloxacin-Loaded Akermanite 3D Porous Scaffolds for Bone Tissue Regeneration
por: Pouroutzidou, Georgia K., et al.
Publicado: (2023)

Optimizing PCL/PLGA Scaffold Biocompatibility Using Gelatin from Bovine, Porcine, and Fish Origin
por: Ghafouri Azar, Mina, et al.
Publicado: (2023)

Minocycline attenuates lipopolysaccharide (LPS)-induced neuroinflammation, sickness behavior, and anhedonia
por: Henry, Christopher J, et al.
Publicado: (2008)

Minocycline Attenuates Cognitive Impairment Induced by Isoflurane Anesthesia in Aged Rats
por: Kong, Feijuan, et al.
Publicado: (2013)

Minocycline attenuates interferon-α-induced impairments in rat fear extinction
por: Bi, Qiang, et al.
Publicado: (2016)

DPD simulations on morphologies and structures of blank PLGA-b-PEG-b-PLGA polymeric micelles and docetaxel-loaded PLGA-b-PEG-b-PLGA polymeric micelles
por: Wang, Mengyao, et al.
Publicado: (2022)

Application of Gelatin Composite Coating in Pork Quality Preservation during Storage and Mechanism of Gelatin Composite Coating on Pork Flavor
por: Li, Haoxin, et al.
Publicado: (2021)

Curcumin-Loaded mPEG-PLGA Nanoparticles Attenuates the Apoptosis and Corticosteroid Resistance Induced by Cigarette Smoke Extract
por: Chen, Xi, et al.
Publicado: (2022)

Neuroprotective effect of insulin-loaded chitosan nanoparticles/PLGA-PEG-PLGA hydrogel on diabetic retinopathy in rats
por: Rong, Xianfang, et al.
Publicado: (2018)

Investigating a Curcumin-Loaded PLGA-PEG-PLGA Thermo-Sensitive Hydrogel for the Prevention of Alzheimer’s Disease
por: Lin, Yi-Wen, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ki2ueefk367rc2jsbt55ih65f1