The rationale behind targeting the ICOS-ICOS ligand costimulatory pathway in cancer immunotherapy

Inducible T cell costimulator (ICOS, cluster of differentiation (CD278)) is an activating costimulatory immune checkpoint expressed on activated T cells. Its ligand, ICOSL is expressed on antigen-presenting cells and somatic cells, including tumour cells in the tumour microenvironment. ICOS and ICOS...

Descripción completa

Detalles Bibliográficos
Autores principales: Solinas, Cinzia, Gu-Trantien, Chunyan, Willard-Gallo, Karen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003380/
https://www.ncbi.nlm.nih.gov/pubmed/32516116
http://dx.doi.org/10.1136/esmoopen-2019-000544

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003380/
https://www.ncbi.nlm.nih.gov/pubmed/32516116
http://dx.doi.org/10.1136/esmoopen-2019-000544

Ejemplares similares