Analysis of the Substrate Specificity of the SMYD2 Protein Lysine Methyltransferase and Discovery of Novel Non‐Histone Substrates

The SMYD2 protein lysine methyltransferase methylates various histone and non‐histone proteins and is overexpressed in several cancers. Using peptide arrays, we investigated the substrate specificity of the enzyme, revealing a recognition of leucine (or weaker phenylalanine) at the −1 peptide site a...

Descripción completa

Detalles Bibliográficos
Autores principales: Weirich, Sara, Schuhmacher, Maren Kirstin, Kudithipudi, Srikanth, Lungu, Cristiana, Ferguson, Andrew D., Jeltsch, Albert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003753/
https://www.ncbi.nlm.nih.gov/pubmed/31612581
http://dx.doi.org/10.1002/cbic.201900582

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003753/
https://www.ncbi.nlm.nih.gov/pubmed/31612581
http://dx.doi.org/10.1002/cbic.201900582

Ejemplares similares