Effects of the ventilatory stimulant, doxapram on human TASK‐3 (KCNK9, K2P9.1) channels and TASK‐1 (KCNK3, K2P3.1) channels

AIMS: The mode of action by which doxapram acts as a respiratory stimulant in humans is controversial. Studies in rodent models, have shown that doxapram is a more potent and selective inhibitor of TASK‐1 and TASK‐1/TASK‐3 heterodimer channels, than TASK‐3. Here we investigate the direct effect of d...

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Detalles Bibliográficos
Autores principales: Cunningham, Kevin P., MacIntyre, D. Euan, Mathie, Alistair, Veale, Emma L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Respiratory and Comparative Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003846/
https://www.ncbi.nlm.nih.gov/pubmed/31423744
http://dx.doi.org/10.1111/apha.13361

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003846/
https://www.ncbi.nlm.nih.gov/pubmed/31423744
http://dx.doi.org/10.1111/apha.13361

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