Acyldepsipeptide Probes Facilitate Specific Detection of Caseinolytic Protease P Independent of Its Oligomeric and Activity State

Caseinolytic protease P (ClpP) is a tetradecameric peptidase that assembles with chaperones such as ClpX to gain proteolytic activity. Acyldepsipeptides (ADEPs) are small‐molecule mimics of ClpX that bind into hydrophobic pockets on the apical site of the complex, thereby activating ClpP. Detection...

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Detalles Bibliográficos
Autores principales: Eyermann, Barbara, Meixner, Maximilian, Brötz‐Oesterhelt, Heike, Antes, Iris, Sieber, Stephan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003903/
https://www.ncbi.nlm.nih.gov/pubmed/31487112
http://dx.doi.org/10.1002/cbic.201900477

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003903/
https://www.ncbi.nlm.nih.gov/pubmed/31487112
http://dx.doi.org/10.1002/cbic.201900477

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