Blocking Sodium‐Taurocholate Cotransporting Polypeptide Stimulates Biliary Cholesterol and Phospholipid Secretion in Mice

Active secretion of bile salts into the canalicular lumen drives bile formation and promotes biliary cholesterol and phospholipid output. Disrupting hepatic bile salt uptake, by inhibition of sodium‐taurocholate cotransporting polypetide (NTCP; Slc10a1) with Myrcludex B, is expected to limit bile sa...

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Detalles Bibliográficos
Autores principales: Roscam Abbing, Reinout L.P., Slijepcevic, Davor, Donkers, Joanne M., Havinga, Rick, Duijst, Suzanne, Paulusma, Coen C., Kuiper, Johan, Kuipers, Folkert, Groen, Albert K., Oude Elferink, Ronald P.J., van de Graaf, Stan F.J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003915/
https://www.ncbi.nlm.nih.gov/pubmed/31136002
http://dx.doi.org/10.1002/hep.30792

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003915/
https://www.ncbi.nlm.nih.gov/pubmed/31136002
http://dx.doi.org/10.1002/hep.30792

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