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Screening of metal ions and organocatalysts on solid support-coupled DNA oligonucleotides guides design of DNA-encoded reactions

DNA-encoded compound libraries are a widely used technology for target-based small molecule screening. Generally, these libraries are synthesized by solution phase combinatorial chemistry requiring aqueous solvent mixtures and reactions that are orthogonal to DNA reactivity. Initiating library synth...

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Detalles Bibliográficos
Autores principales: Potowski, Marco, Losch, Florian, Wünnemann, Elena, Dahmen, Janina K., Chines, Silvia, Brunschweiger, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003951/
https://www.ncbi.nlm.nih.gov/pubmed/32055372
http://dx.doi.org/10.1039/c9sc04708e