Sidechain Diversification of Grandifloracin Allows Identification of Analogues with Enhanced Anti‐Austerity Activity against Human PANC‐1 Pancreatic Cancer Cells

The natural product (+)‐grandifloracin is a potent “anti‐austerity” agent, able to suppress the ability of various pancreatic cancer cell lines to tolerate conditions of nutrient deprivation. Such anti‐austerity agents represent a promising approach to cancer chemotherapy. Here we report the synthes...

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Detalles Bibliográficos
Autores principales: Alexander, Benjamin E., Sun, Sijia, Palframan, Matthew J., Kociok‐Köhn, Gabriele, Dibwe, Dya Fita, Watanabe, Shiro, Caggiano, Lorenzo, Awale, Suresh, Lewis, Simon E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003952/
https://www.ncbi.nlm.nih.gov/pubmed/31821731
http://dx.doi.org/10.1002/cmdc.201900549

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003952/
https://www.ncbi.nlm.nih.gov/pubmed/31821731
http://dx.doi.org/10.1002/cmdc.201900549

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