Structure‐Based Design of a Macrocyclic PROTAC

Constraining a molecule in its bioactive conformation via macrocyclization represents an attractive strategy to rationally design functional chemical probes. While this approach has been applied to enzyme inhibitors or receptor antagonists, to date it remains unprecedented for bifunctional molecules...

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Detalles Bibliográficos
Autores principales: Testa, Andrea, Hughes, Scott J., Lucas, Xavier, Wright, Jane E., Ciulli, Alessio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7004083/
https://www.ncbi.nlm.nih.gov/pubmed/31746102
http://dx.doi.org/10.1002/anie.201914396

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7004083/
https://www.ncbi.nlm.nih.gov/pubmed/31746102
http://dx.doi.org/10.1002/anie.201914396

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