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Probing remote residues important for catalysis in Escherichia coli ornithine transcarbamoylase

Understanding how enzymes achieve their tremendous catalytic power is a major question in biochemistry. Greater understanding is also needed for enzyme engineering applications. In many cases, enzyme efficiency and specificity depend on residues not in direct contact with the substrate, termed remot...

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Detalles Bibliográficos
Autores principales: Ngu, Lisa, Winters, Jenifer N., Nguyen, Kien, Ramos, Kevin E., DeLateur, Nicholas A., Makowski, Lee, Whitford, Paul C., Ondrechen, Mary Jo, Beuning, Penny J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7004355/
https://www.ncbi.nlm.nih.gov/pubmed/32027716
http://dx.doi.org/10.1371/journal.pone.0228487