Nucleotide inhibition of the pancreatic ATP-sensitive K(+) channel explored with patch-clamp fluorometry

Pancreatic ATP-sensitive K(+) channels (K(ATP)) comprise four inward rectifier subunits (Kir6.2), each associated with a sulphonylurea receptor (SUR1). ATP/ADP binding to Kir6.2 shuts K(ATP). Mg-nucleotide binding to SUR1 stimulates K(ATP). In the absence of Mg(2+), SUR1 increases the apparent affin...

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Detalles Bibliográficos
Autores principales: Usher, Samuel G, Ashcroft, Frances M, Puljung, Michael C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7004565/
https://www.ncbi.nlm.nih.gov/pubmed/31909710
http://dx.doi.org/10.7554/eLife.52775

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7004565/
https://www.ncbi.nlm.nih.gov/pubmed/31909710
http://dx.doi.org/10.7554/eLife.52775

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