Cargando…
Nucleotide inhibition of the pancreatic ATP-sensitive K(+) channel explored with patch-clamp fluorometry
Pancreatic ATP-sensitive K(+) channels (K(ATP)) comprise four inward rectifier subunits (Kir6.2), each associated with a sulphonylurea receptor (SUR1). ATP/ADP binding to Kir6.2 shuts K(ATP). Mg-nucleotide binding to SUR1 stimulates K(ATP). In the absence of Mg(2+), SUR1 increases the apparent affin...
| Autores principales: | , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2020
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7004565/ https://www.ncbi.nlm.nih.gov/pubmed/31909710 http://dx.doi.org/10.7554/eLife.52775 |