A new experimental mouse model of water intoxication with sustained increased intracranial pressure and mild hyponatremia without side effects of antidiuretics

The most used experimental mouse model of hyponatremia and elevated intracranial pressure (ICP) is intraperitoneal injection of water in combination with antidiuretics. This model of water intoxication (WI) results in extreme pathological changes and death within 1 h. To improve preclinical studies...

Descripción completa

Detalles Bibliográficos
Autores principales: Bordoni, Luca, Jiménez, Eugenio Gutiérrez, Nielsen, Søren, Østergaard, Leif, Frische, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Association for Laboratory Animal Science 2019
Materias:
Original
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7004811/
https://www.ncbi.nlm.nih.gov/pubmed/31534063
http://dx.doi.org/10.1538/expanim.19-0040

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7004811/
https://www.ncbi.nlm.nih.gov/pubmed/31534063
http://dx.doi.org/10.1538/expanim.19-0040

Ejemplares similares