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BIOPHYSICAL PREDICTION OF PROTEIN-PEPTIDE INTERACTIONS AND SIGNALING NETWORKS USING MACHINE LEARNING
In mammalian cells, much of signal transduction is mediated by weak protein-protein interactions between globular peptide-binding domains (PBDs) and unstructured peptidic motifs in partner proteins. The number and diversity of these PBDs (over 1,800 are known), low binding affinities, and sensitivit...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7004877/ https://www.ncbi.nlm.nih.gov/pubmed/31907444 http://dx.doi.org/10.1038/s41592-019-0687-1 |