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BIOPHYSICAL PREDICTION OF PROTEIN-PEPTIDE INTERACTIONS AND SIGNALING NETWORKS USING MACHINE LEARNING

In mammalian cells, much of signal transduction is mediated by weak protein-protein interactions between globular peptide-binding domains (PBDs) and unstructured peptidic motifs in partner proteins. The number and diversity of these PBDs (over 1,800 are known), low binding affinities, and sensitivit...

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Detalles Bibliográficos
Autores principales: Cunningham, Joseph M., Koytiger, Grigoriy, Sorger, Peter K., AlQuraishi, Mohammed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7004877/
https://www.ncbi.nlm.nih.gov/pubmed/31907444
http://dx.doi.org/10.1038/s41592-019-0687-1

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