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Activated Bone Marrow-Derived Macrophages Eradicate Alzheimer's-Related Aβ(42) Oligomers and Protect Synapses

Impaired synaptic integrity and function due to accumulation of amyloid β-protein (Aβ(42)) oligomers is thought to be a major contributor to cognitive decline in Alzheimer's disease (AD). However, the exact role of Aβ(42) oligomers in synaptotoxicity and the ability of peripheral innate immune...

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Detalles Bibliográficos
Autores principales: Li, Songlin, Hayden, Eric Y., Garcia, Veronica J., Fuchs, Dieu-Trang, Sheyn, Julia, Daley, David A., Rentsendorj, Altan, Torbati, Tania, Black, Keith L., Rutishauser, Ueli, Teplow, David B., Koronyo, Yosef, Koronyo-Hamaoui, Maya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005081/
https://www.ncbi.nlm.nih.gov/pubmed/32082319
http://dx.doi.org/10.3389/fimmu.2020.00049