A combination strategy targeting enhancer plasticity exerts synergistic lethality against BETi-resistant leukemia cells

Primary and acquired drug resistance imposes a major threat to achieving optimized clinical outcomes during cancer treatment. Aberrant changes in epigenetic modifications are closely involved in drug resistance of tumor cells. Using BET inhibitor (BETi) resistant leukemia cells as a model system, we...

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Detalles Bibliográficos
Autores principales: Guo, Lei, Li, Jia, Zeng, Hongxiang, Guzman, Anna G., Li, Tingting, Lee, Minjung, Zhou, Yubin, Goodell, Margaret A., Stephan, Clifford, Davies, Peter J. A., Dawson, Mark A, Sun, Deqiang, Huang, Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005144/
https://www.ncbi.nlm.nih.gov/pubmed/32029739
http://dx.doi.org/10.1038/s41467-020-14604-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005144/
https://www.ncbi.nlm.nih.gov/pubmed/32029739
http://dx.doi.org/10.1038/s41467-020-14604-6

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